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Palustrin-2ISb (1-29), GL-29
General Information
DRACP ID DRACP02359
Peptide Name Palustrin-2ISb (1-29), GL-29
Sequence GLWNSIKIAGKKLFVNVLDKIRCKVAGGC
Sequence Length 29
UniProt ID G5ELM2
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| U-251MG | Astrocytoma | Carcinoma | IC50=6.6 μM | MTT assay | 24 h | 1 |
| HCT 116 | Colon carcinoma | Carcinoma | IC50=17.86 μM | MTT assay | 24 h | 1 |
| H157 | Buccal mucosa squamous cell carcinoma; Squamous cell carcinoma of the oral cavity | Carcinoma | IC50=1.74 μM | MTT assay | 24 h | 1 |
| NCI-H838 | Lung adenocarcinoma | Carcinoma | IC50=5.38 μM | MTT assay | 24 h | 1 |
Hemolytic Activity Horse erythrocytes: 10% Hemolysis=5.86 µM; 50% Hemolysis=33.03 µM
Normal (non-cancerous) Cytotoxicity Human keratinocytes HaCat: IC50=5.05 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys23<--->Cys29
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C142H240N40O35S2
Absent amino acids EHMPQTY
Common amino acids K
Mass 363148
Pl 10.63
Basic residues 6
Acidic residues 1
Hydrophobic residues 13
Net charge 5
Boman Index -1118
Hydrophobicity 38.28
Aliphatic Index 117.59
Half Life
Mammalian:
Yeast:
E.coli:
Extinction Coefficient cystines 5625
Absorbance 280nm 200.89
Polar residues 9
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 36009917
Title Targeted Modification and Structure-Activity Study of GL-29, an Analogue of the Antimicrobial Peptide Palustrin-2ISb
Doi 10.3390/antibiotics11081048
Year 2022
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4313
This work is licensed under a Creative Commons Attribution 4.0 International License.