Peptide Libraray

GL-22

General Information

DRACP ID DRACP02360

Peptide Name GL-22

Sequence GLWNSIKIAGKKLFVNVLDKIR

Sequence Length 22

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
U-251MG	Astrocytoma	Carcinoma	IC50=40.58 μM	MTT assay	24 h	1
HCT 116	Colon carcinoma	Carcinoma	IC50=128.89 μM	MTT assay	24 h	1
H157	Buccal mucosa squamous cell carcinoma; Squamous cell carcinoma of the oral cavity	Carcinoma	IC50=9.36 μM	MTT assay	24 h	1
NCI-H838	Lung adenocarcinoma	Carcinoma	IC50=25.25 μM	MTT assay	24 h	1

Hemolytic Activity Horse erythrocytes: 10% Hemolysis=87.304 µM; 50% Hemolysis=254.11 µM

Normal (non-cancerous) Cytotoxicity Human keratinocytes HaCat: IC50=38.90 µM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antibacterial; Antifungal

Structure Information

PDB ID Not available

Predicted Structure DRACP02360

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C118H198N32O28

Absent amino acids CEHMPQTY

Common amino acids K

Mass 288784

Pl 11.25

Basic residues 5

Acidic residues 1

Hydrophobic residues 11

Net charge 4

Boman Index -1592

Hydrophobicity 21.82

Aliphatic Index 137.27

Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 261.9

Polar residues 5

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 36009917

Title Targeted Modification and Structure-Activity Study of GL-29, an Analogue of the Antimicrobial Peptide Palustrin-2ISb

Doi 10.3390/antibiotics11081048

Year 2022

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available