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SK84
General Information
DRACP ID DRACP02362
Peptide Name SK84
Sequence SQLGDLGSGAGQGGGGGGSIRAAGGAFGKLEAAREEEFFYKKQKEQLERLKNDQIHQAEFHHQQIKEHEEAIQRHKDFLNNLHK
Sequence Length 84
UniProt ID B4LLX1
PubChem CID Not available
Origin Drosophila virilis
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| THP-1 | Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia | Leukemia | IC50=35 µM | MTS assay | 72 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=50 µM | MTS assay | 72 h | 1 |
| HepG2 | Hepatoblastoma | Blastoma | IC50=92 µM | MTS assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C406H632N128O127
Absent amino acids CMPTVW
Common amino acids G
Mass 1081896
Pl 7.18
Basic residues 18
Acidic residues 13
Hydrophobic residues 24
Net charge 5
Boman Index -21070
Hydrophobicity -109.29
Aliphatic Index 60.6
Half Life
Mammalian: 2.8 hour
Yeast: 10 min
E.coli: 2 min
Extinction Coefficient cystines 1490
Absorbance 280nm 17.95
Polar residues 20
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19799950
Title Isolation, characterization and anti-cancer activity of SK84, a novel glycine-rich antimicrobial peptide from Drosophila virilis
Doi 10.1016/j.peptides.2009.09.028
Year 2010
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4323
This work is licensed under a Creative Commons Attribution 4.0 International License.