This work is licensed under a Creative Commons Attribution 4.0 International License.
Alyteserin-2b
General Information
DRACP ID DRACP02363
Peptide Name Alyteserin-2b
Sequence ILGAILPLVSGLLSNKL
Sequence Length 17
UniProt ID Not available
PubChem CID Not available
Origin Alytes obstetricans
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | LC50>100 µM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=115 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C81H145N19O21
Absent amino acids CDEFHMQRTWY
Common amino acids L
Mass 200675
Pl 9.7
Basic residues 1
Acidic residues 0
Hydrophobic residues 10
Net charge 1
Boman Index 2810
Hydrophobicity 155.29
Aliphatic Index 206.47
Half Life
Mammalian: 1.9 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22392897
Title Analogues of the frog skin peptide alyteserin-2a with enhanced antimicrobial activities against Gram-negative bacteria
Doi 10.1002/psc.2397
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4393
This work is licensed under a Creative Commons Attribution 4.0 International License.