This work is licensed under a Creative Commons Attribution 4.0 International License.
Pentadactylin
General Information
DRACP ID DRACP02364
Peptide Name Pentadactylin
Sequence GLLDTLKGAAKNVVGSLASKVMEKL
Sequence Length 25
UniProt ID P0DQJ7
PubChem CID Not available
Origin Leptodactylus pentadactylus
Type Native peptide
Classification
Active ACP Induce apoptosis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| B16-F10 | Mouse melanoma | Carcinoma | IC50=25.7 µM | MTT assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Human fibroblasts FHN: IC50=35.9 µM
Target Not available
Affinity Not available
Mechanism In the present study the rounding and cell shrinkage, DNA fragmentation, mitochondrial membrane potential alteration and S phase arrest support the apoptogenic nature of pentadactylin, whereas cell growth inhibition and reduction of cell viability indicate its anti-proliferative and cytotoxic activity.
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C112H200N30O34S
Absent amino acids CFHIPQRWY
Common amino acids L
Mass 297135
Pl 10.33
Basic residues 4
Acidic residues 2
Hydrophobic residues 11
Net charge 2
Boman Index -642
Hydrophobicity 37.2
Aliphatic Index 124.8
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 20012549
Title Anti-proliferative and cytotoxic activity of pentadactylin isolated from Leptodactylus labyrinthicus on melanoma cells
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4394
This work is licensed under a Creative Commons Attribution 4.0 International License.