Linear Cyclotide Panitide L1

General Information


DRACP ID  DRACP02365

Peptide Name   Linear Cyclotide Panitide L1

Sequence  XLPICGETCVLGTCYTPGCRCQYPICVR

Sequence Length  28

UniProt ID  K9Y490 

PubChem CID  Not available

Origin  Steinchisma laxum (Panicum laxum)

Type  Native peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma IC50=4.1 µM PrestoBlue cell viability reagent 48 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys5<--->Cys19; Cys9<--->Cys21; Cys14<--->Cys26

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  X=PYA (Pyroglutamic acid)

Chiral  L



Physicochemical Information


Formula  C125H200N34O35S6

Absent amino acids  ADFHKMNSW

Common amino acids  C

Mass  352332

Pl  7.73

Basic residues  2

Acidic residues  1

Hydrophobic residues  6

Net charge  1

Boman Index  -1192

Hydrophobicity  47.5

Aliphatic Index  76.43

Half Life 
  /

Extinction Coefficient cystines  3355

Absorbance 280nm  124.26

Polar residues  14

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 23195955

Title  Discovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants

Doi 10.1074/jbc.M112.415356

Year  2013

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPR_4458

DRACP is developed by Dr.Zheng's team.