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Linear Cyclotide Panitide L2
General Information
DRACP ID DRACP02366
Peptide Name Linear Cyclotide Panitide L2
Sequence XLPICGETCVLGRCYTPNCRCQYPICVR
Sequence Length 28
UniProt ID K9Y2Z0
PubChem CID Not available
Origin Steinchisma laxum (Panicum laxum)
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=6 µM | PrestoBlue cell viability reagent | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys5<--->Cys19; Cys9<--->Cys21; Cys14<--->Cys26
N-terminal Modification Free
C-terminal Modification Free
Other Modification X=PYA (Pyroglutamic acid)
Chiral L
Physicochemical Information
Formula C129H208N38O35S6
Absent amino acids ADFHKMSW
Common amino acids C
Mass 363545
Pl 8.11
Basic residues 3
Acidic residues 1
Hydrophobic residues 6
Net charge 2
Boman Index -3185
Hydrophobicity 22.86
Aliphatic Index 76.43
Half Life
/
Extinction Coefficient cystines 3355
Absorbance 280nm 124.26
Polar residues 13
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23195955
Title Discovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4459
This work is licensed under a Creative Commons Attribution 4.0 International License.