This work is licensed under a Creative Commons Attribution 4.0 International License.
Linear Cyclotide Panitide L4
General Information
DRACP ID DRACP02368
Peptide Name Linear Cyclotide Panitide L4
Sequence XAFCGETCLLGTCYTPGCRCTAGICLK
Sequence Length 27
UniProt ID K9Y385
PubChem CID Not available
Origin Steinchisma laxum (Panicum laxum)
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50>10 µM | PrestoBlue cell viability reagent | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys4<--->Cys18; Cys8<--->Cys20; Cys13<--->Cys25
N-terminal Modification Free
C-terminal Modification Free
Other Modification X=PYA (Pyroglutamic acid)
Chiral L
Physicochemical Information
Formula C112H180N30O33S6
Absent amino acids DHMNQSVW
Common amino acids C
Mass 324117
Pl 7.73
Basic residues 2
Acidic residues 1
Hydrophobic residues 7
Net charge 1
Boman Index 2
Hydrophobicity 67.04
Aliphatic Index 65.19
Half Life
/
Extinction Coefficient cystines 1865
Absorbance 280nm 71.73
Polar residues 15
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23195955
Title Discovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4461
This work is licensed under a Creative Commons Attribution 4.0 International License.