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Psalmopeotoxin I, PcFK1
General Information
DRACP ID DRACP02373
Peptide Name Psalmopeotoxin I, PcFK1
Sequence ACGILHDNCVYVPAQNPCCRGLQCRYGKCLVQV
Sequence Length 33
UniProt ID P0C201
PubChem CID Not available
Origin Psalmopoeus cambridgei
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa 229 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | Not active up to 50 µM | PI and Annexin-V-FITC double-staining | 48 h | 1 |
Hemolytic Activity Human erythrocytes: Not active at 10 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys2<--->Cys19; Cys9<--->Cys24; Cys18<--->Cys29
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C153H247N47O43S6
Absent amino acids EFMSTW
Common amino acids C
Mass 419630
Pl 8.12
Basic residues 4
Acidic residues 1
Hydrophobic residues 10
Net charge 3
Boman Index -2899
Hydrophobicity 21.82
Aliphatic Index 88.48
Half Life
Mammalian:
Yeast:
E.coli:
Extinction Coefficient cystines 3355
Absorbance 280nm 104.84
Polar residues 13
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 15304333
Title Isolation and characterization of Psalmopeotoxin I and II: two novel antimalarial peptides from the venom of the tarantula Psalmopoeus cambridgei
Doi 10.1016/j.febslet.2004.07.019
Year 2004
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4467
This work is licensed under a Creative Commons Attribution 4.0 International License.