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Psalmopeotoxin II, PcFK2
General Information
DRACP ID DRACP02374
Peptide Name Psalmopeotoxin II, PcFK2
Sequence RCLPAGKTCVRGPMRVPCCGSCSQNKCT
Sequence Length 28
UniProt ID P0C202
PubChem CID Not available
Origin Psalmopoeus cambridgei
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa 229 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | Not active up to 50 µM | PI and Annexin-V-FITC double-staining | 48 h | 1 |
Hemolytic Activity Human erythrocytes: Not active at 10 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys2<--->Cys19; Cys9<--->Cys22; Cys18<--->Cys27
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C116H203N41O35S7
Absent amino acids DEFHIWY
Common amino acids C
Mass 343834
Pl 8.9
Basic residues 5
Acidic residues 0
Hydrophobic residues 4
Net charge 5
Boman Index -5232
Hydrophobicity -22.86
Aliphatic Index 38.21
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 375
Absorbance 280nm 13.89
Polar residues 14
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 15304333
Title Isolation and characterization of Psalmopeotoxin I and II: two novel antimalarial peptides from the venom of the tarantula Psalmopoeus cambridgei
Doi 10.1016/j.febslet.2004.07.019
Year 2004
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4466
This work is licensed under a Creative Commons Attribution 4.0 International License.