Psalmopeotoxin II, PcFK2

General Information


DRACP ID  DRACP02374

Peptide Name   Psalmopeotoxin II, PcFK2

Sequence  RCLPAGKTCVRGPMRVPCCGSCSQNKCT

Sequence Length  28

UniProt ID  P0C202 

PubChem CID  Not available

Origin  Psalmopoeus cambridgei

Type  Native peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HeLa 229 Human papillomavirus-related endocervical adenocarcinoma Carcinoma Not active up to 50 µM PI and Annexin-V-FITC double-staining 48 h 1

Hemolytic Activity  Human erythrocytes: Not active at 10 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02374

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys2<--->Cys19; Cys9<--->Cys22; Cys18<--->Cys27

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C116H203N41O35S7

Absent amino acids  DEFHIWY

Common amino acids  C

Mass  343834

Pl  8.9

Basic residues  5

Acidic residues  0

Hydrophobic residues  4

Net charge  5

Boman Index  -5232

Hydrophobicity  -22.86

Aliphatic Index  38.21

Half Life 
  Mammalian: 4.4 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  375

Absorbance 280nm  13.89

Polar residues  14

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 15304333

Title  Isolation and characterization of Psalmopeotoxin I and II: two novel antimalarial peptides from the venom of the tarantula Psalmopoeus cambridgei

Doi 10.1016/j.febslet.2004.07.019

Year  2004

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPR_4466

DRACP is developed by Dr.Zheng's team.