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Cathelicidin CATH3, Cc-CATH3
General Information
DRACP ID DRACP02376
Peptide Name Cathelicidin CATH3, Cc-CATH3
Sequence RVRRFWPLVPVAINTVAAGINLYKAIRRK
Sequence Length 29
UniProt ID D1MJ09
PubChem CID Not available
Origin Coturnix coturnix
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| RAW 264.7 | Mouse leukemia | Leukemia | IC50=58 µg/ml | MTT assay | 48 h | 1 |
Hemolytic Activity Human erythrocytes: 3.6% Hemolysis=100 µg/ml
Normal (non-cancerous) Cytotoxicity HUVEC: IC50=58 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C157H261N49O34
Absent amino acids CDEHMQS
Common amino acids R
Mass 387872
Pl 12.69
Basic residues 7
Acidic residues 0
Hydrophobic residues 15
Net charge 7
Boman Index -4744
Hydrophobicity 14.14
Aliphatic Index 121.03
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 6990
Absorbance 280nm 249.64
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21375690
Title Gene cloning, expression and characterization of avian cathelicidin orthologs, Cc-CATHs, from Coturnix coturnix
Doi 10.1111/j.1742-4658.2011.08080.x
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4477
This work is licensed under a Creative Commons Attribution 4.0 International License.