This work is licensed under a Creative Commons Attribution 4.0 International License.
PTP-7c
General Information
DRACP ID DRACP02377
Peptide Name PTP-7c
Sequence FLGALFHALSHLL
Sequence Length 13
UniProt ID P80399
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| PANC-1 | Pancreatic ductal adenocarcinoma | Carcinoma | IC50>120 μM | MTT assay | 2 h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | IC50>160 μM | MTT assay | 2 h | 1 |
Hemolytic Activity Human erythrocytes: 0% Hemolysis=30 µM
Normal (non-cancerous) Cytotoxicity MCF-10A: IC50>120 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C71H107N17O15
Absent amino acids CDEIKMNPQRTVWY
Common amino acids L
Mass 165298
Pl 7.72
Basic residues 2
Acidic residues 0
Hydrophobic residues 9
Net charge 2
Boman Index 2240
Hydrophobicity 158.46
Aliphatic Index 165.38
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22526264
Title Activity and selectivity of histidine-containing lytic peptides to antibiotic-resistant bacteria
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4526
This work is licensed under a Creative Commons Attribution 4.0 International License.