This work is licensed under a Creative Commons Attribution 4.0 International License.
D-LAK160-HP13
General Information
DRACP ID DRACP02389
Peptide Name D-LAK160-HP13
Sequence kkalkhalakwlpalkalahklakk
Sequence Length 25
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | EC50=7.58 ± 0.42 μM | MTT assay | 4 h | 1 |
| RAW 264.7 | Mouse leukemia | Leukemia | EC50=3.95 ± 0.40 μM | MTT assay | 4 h | 1 |
Hemolytic Activity Human erythrocytes: HC50=185.0±18.65 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral D
Physicochemical Information
Formula H-48O-24
Absent amino acids ACDEFGHIKLMNPQRSTVWY
Common amino acids ACDEFGHIKLMNPQRSTVWYX
Mass -414
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 0
Net charge 0
Boman Index 0
Hydrophobicity 0
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22869378
Title Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic α-helical peptides
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4506
This work is licensed under a Creative Commons Attribution 4.0 International License.