L5c

General Information


DRACP ID  DRACP02392

Peptide Name   L5c

Sequence  PAWRHAFHWAWHMLHKAA

Sequence Length  18

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Membrane lysis



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
A549 Lung adenocarcinoma Carcinoma IC50>80 μM(pH=7.4); IC50=12 ± 2 μM(pH=5.5) MTT assay 2 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  CHO: IC50=67 ± 3 μM(pH=7.4); IC50=7 ± 2 μM(pH=5.5)

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02392

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C109H145N33O19S

Absent amino acids  CDEGINQSTVY

Common amino acids  A

Mass  255705

Pl  11.65

Basic residues  6

Acidic residues  0

Hydrophobic residues  10

Net charge  6

Boman Index  -1282

Hydrophobicity  -44.44

Aliphatic Index  49.44

Half Life 
  Mammalian: >20 hour
  Yeast: >20 hour
  E.coli: ?

Extinction Coefficient cystines  16500

Absorbance 280nm  970.59

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 19464332

Title  Constructing bioactive peptides with pH-dependent activities

Doi 10.1016/j.peptides.2009.05.009

Year  2009

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_4530

DRACP is developed by Dr.Zheng's team.