This work is licensed under a Creative Commons Attribution 4.0 International License.
L5c
General Information
DRACP ID DRACP02392
Peptide Name L5c
Sequence PAWRHAFHWAWHMLHKAA
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50>80 μM(pH=7.4); IC50=12 ± 2 μM(pH=5.5) | MTT assay | 2 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity CHO: IC50=67 ± 3 μM(pH=7.4); IC50=7 ± 2 μM(pH=5.5)
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C109H145N33O19S
Absent amino acids CDEGINQSTVY
Common amino acids A
Mass 255705
Pl 11.65
Basic residues 6
Acidic residues 0
Hydrophobic residues 10
Net charge 6
Boman Index -1282
Hydrophobicity -44.44
Aliphatic Index 49.44
Half Life
Mammalian: >20 hour
Yeast: >20 hour
E.coli: ?
Extinction Coefficient cystines 16500
Absorbance 280nm 970.59
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19464332
Title Constructing bioactive peptides with pH-dependent activities
Doi 10.1016/j.peptides.2009.05.009
Year 2009
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4530
This work is licensed under a Creative Commons Attribution 4.0 International License.