This work is licensed under a Creative Commons Attribution 4.0 International License.
Citropin-c
General Information
DRACP ID DRACP02395
Peptide Name Citropin-c
Sequence GLFAVIHHVASVIGGL
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=156 ± 7 μM(pH=7.4); IC50=36 ± 2 μM(pH=5.5) | MTT assay | 2 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity CHO: IC50>120 μM(pH=7.4); IC50>120 μM(pH=5.5)
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C75H120N20O18
Absent amino acids CDEKMNPQRTWY
Common amino acids GV
Mass 185766
Pl 7.72
Basic residues 2
Acidic residues 0
Hydrophobic residues 10
Net charge 2
Boman Index 2850
Hydrophobicity 170
Aliphatic Index 164.38
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19464332
Title Constructing bioactive peptides with pH-dependent activities
Doi 10.1016/j.peptides.2009.05.009
Year 2009
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4534
This work is licensed under a Creative Commons Attribution 4.0 International License.