This work is licensed under a Creative Commons Attribution 4.0 International License.
SolyC
General Information
DRACP ID DRACP02397
Peptide Name SolyC
Sequence FSGGNCRGFRRRCFCTK
Sequence Length 17
UniProt ID K4CBP6
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| THP-1 | Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia | Leukemia | Not active up to 120 µg/ml | Trypan blue assay | 24, 48, 72 h | 1 |
Hemolytic Activity Human erythrocytes: HC50=270 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C83H131N31O21S3
Absent amino acids ADEHILMPQVWY
Common amino acids R
Mass 228088
Pl 11.31
Basic residues 5
Acidic residues 0
Hydrophobic residues 3
Net charge 5
Boman Index -6224
Hydrophobicity -71.76
Aliphatic Index 0
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 125
Absorbance 280nm 7.81
Polar residues 9
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23124812
Title A novel synthetic peptide from a tomato defensin exhibits antibacterial activities against Helicobacter pylori
Doi 10.1002/psc.2462
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4545
This work is licensed under a Creative Commons Attribution 4.0 International License.