This work is licensed under a Creative Commons Attribution 4.0 International License.
Temporin-1Sa [S3K], SEQ ID NO:29 for Patent EP 2853538 A1
General Information
DRACP ID DRACP02400
Peptide Name Temporin-1Sa [S3K], SEQ ID NO:29 for Patent EP 2853538 A1
Sequence FLKGIVGMLGKLE
Sequence Length 13
UniProt ID B3KYH4
PubChem CID Not available
Origin Synthetic (Derived from Temporin-1Sa)
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| THP-1 | Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia | Leukemia | IC50=48 μM | MTT assay | 72 h | Patent |
| HepG2 | Hepatoblastoma | Blastoma | LC50=358 μM | MTT assay | 72 h | Patent |
Hemolytic Activity Rat erythrocytes: LC50=26 µM
Normal (non-cancerous) Cytotoxicity Human fibroblasts: LC50>100 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C66H113N15O16S
Absent amino acids ACDHNPQRSTWY
Common amino acids GL
Mass 161901
Pl 9.54
Basic residues 2
Acidic residues 1
Hydrophobic residues 6
Net charge 1
Boman Index 1396
Hydrophobicity 94.62
Aliphatic Index 142.31
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID EP 2853538 A1
Patent Title Analogues of temporin-SHa and uses thereof
Other Iinformation Patent Application; Family: 11s / 11ex; Family Jurisdictions: CA, EP, JP, BR, US, WO, ES; Legal Status: Discontinued; Application No: 13306344; Filed: Sep 27, 2013; Published: Apr 1, 2015; Earliest Priority: Sep 27, 2013
Other Published ID BR112016006424A2 CA2924035A1 EP3049432A1 EP3049432B1 ES2691323T3 JP2016539658A JP6669656B2 US2016280749A1 US9932376B2 WO2015044356A1
This work is licensed under a Creative Commons Attribution 4.0 International License.