This work is licensed under a Creative Commons Attribution 4.0 International License.
N8
General Information
DRACP ID DRACP02420
Peptide Name N8
Sequence LIKRK
Sequence Length 5
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | Leukemia | LD50>64 µM; MTC>64 µM | CytoTox 96 non-radiactive cytotoxicity assay | 2 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C30H60N10O6
Absent amino acids ACDEFGHMNPQSTVWY
Common amino acids K
Mass 72840
Pl 11.82
Basic residues 3
Acidic residues 0
Hydrophobic residues 2
Net charge 3
Boman Index -1618
Hydrophobicity -80
Aliphatic Index 156
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25192319
Title Rational design of artificial β-strand-forming antimicrobial peptides with biocompatible properties
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_8973
This work is licensed under a Creative Commons Attribution 4.0 International License.