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Trichogin GA IV, TG
General Information
DRACP ID DRACP02451
Peptide Name Trichogin GA IV, TG
Sequence XGLXGGLXGIX
Sequence Length 11
UniProt ID Not available
PubChem CID 101039518
Origin Trichoderma longibrachiatum
Type Native peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| T67 | Astrocytoma | Carcinoma | EC50=2 μM | MTT assay | 24 h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | EC50=8 μM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Human dermal fibroblasts: EC50=4 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Oct (Fatty acid 1-Octanoyl)
C-terminal Modification Free
Other Modification X(1/4/8)=Aib; X(11)=Lol (Amino alcohol leucinol)
Chiral L
Physicochemical Information
Formula C26H39N7O4
Absent amino acids ACDEFHKMNPQRSTVWY
Common amino acids GX
Mass 113220
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 3
Net charge 0
Boman Index 1852
Hydrophobicity 95.45
Aliphatic Index 106.36
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27039838
Title The rational search for selective anticancer derivatives of the peptide Trichogin GA IV: a multi-technique biophysical approach
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_4876
This work is licensed under a Creative Commons Attribution 4.0 International License.