This work is licensed under a Creative Commons Attribution 4.0 International License.
[TOAC1, Lys5,6] TG
General Information
DRACP ID DRACP02459
Peptide Name [TOAC1, Lys5,6] TG
Sequence XGLXKKLXGIX
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Synthetic (Derived from TG)
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| T67 | Astrocytoma | Carcinoma | EC50=10 μM | MTT assay | 24 h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | EC50=6 μM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Human dermal fibroblasts: EC50=15 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Oct (Fatty acid 1-Octanoyl)
C-terminal Modification Free
Other Modification X(1)=TOAC; X(4/8)=Aib; X(11)=Lol (Amino alcohol leucinol)
Chiral L
Physicochemical Information
Formula C34H57N9O4
Absent amino acids ACDEFHMNPQRSTVWY
Common amino acids X
Mass 127444
Pl 10.81
Basic residues 2
Acidic residues 0
Hydrophobic residues 3
Net charge 2
Boman Index 554
Hydrophobicity 31.82
Aliphatic Index 106.36
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27039838
Title The rational search for selective anticancer derivatives of the peptide Trichogin GA IV: a multi-technique biophysical approach
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_9393
This work is licensed under a Creative Commons Attribution 4.0 International License.