[TOAC1, Leu8] TG

General Information


DRACP ID  DRACP02464

Peptide Name   [TOAC1, Leu8] TG

Sequence  XGLXGGLLGIX

Sequence Length  11

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic (Derived from TG)

Type  Synthetic peptide

Classification

  

Active ACP Membrane lysis



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
T67 Astrocytoma Carcinoma Not active up to 20 μM MTT assay 24 h 1
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma Not active up to 20 μM MTT assay 24 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Human dermal fibroblasts: Not active up to 20 μM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Oct (Fatty acid 1-Octanoyl)

C-terminal Modification  Free

Other Modification  X(1)=TOAC; X(4)=Aib; X(11)=Lol (Amino alcohol leucinol)

Chiral  L



Physicochemical Information


Formula  C32H52N8O6

Absent amino acids  ACDEFHKMNPQRSTVWY

Common amino acids  G

Mass  115338

Pl  6.11

Basic residues  0

Acidic residues  0

Hydrophobic residues  4

Net charge  0

Boman Index  2344

Hydrophobicity  130

Aliphatic Index  141.82

Half Life 
  /

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  4

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 27039838

Title  The rational search for selective anticancer derivatives of the peptide Trichogin GA IV: a multi-technique biophysical approach

Doi 10.1038/srep24000

Year  2016

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_9396

DRACP is developed by Dr.Zheng's team.