This work is licensed under a Creative Commons Attribution 4.0 International License.
[Lys4] Ascaphin-8
General Information
DRACP ID DRACP02466
Peptide Name [Lys4] Ascaphin-8
Sequence GFKKLLKGAAKALVKTVLF
Sequence Length 19
UniProt ID P0CJ32
PubChem CID Not available
Origin Synthetic (Derived from Ascaphin-8)
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Blastoma | LC50=12 µM | CytoTox 96 non-radiactive cytotoxicity assay | 1 h | 1 |
Hemolytic Activity Human erythrocytes: LC50=24 µM
Normal (non-cancerous) Cytotoxicity L929 fibroblast-derived cells: LC50=5 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C99H170N24O21
Absent amino acids CDEHIMNPQRSWY
Common amino acids K
Mass 235385
Pl 11.4
Basic residues 5
Acidic residues 0
Hydrophobic residues 11
Net charge 5
Boman Index 1071
Hydrophobicity 71.58
Aliphatic Index 128.42
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 18554256
Title Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7
Doi 10.1111/j.1747-0285.2008.00671.x
Year 2008
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4900
This work is licensed under a Creative Commons Attribution 4.0 International License.