[Lys18] Ascaphin-8

General Information


DRACP ID  DRACP02470

Peptide Name   [Lys18] Ascaphin-8

Sequence  GFKDLLKGAAKALVKTVKF

Sequence Length  19

UniProt ID  P0CJ32 

PubChem CID  Not available

Origin  Synthetic (Derived from Ascaphin-8)

Type  Synthetic peptide

Classification

  

Active ACP Membrane lysis



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HepG2 Hepatoblastoma Blastoma LC50=200 µM CytoTox 96 non-radiactive cytotoxicity assay  1 h 1

Hemolytic Activity  Human erythrocytes: LC50>500 µM

Normal (non-cancerous) Cytotoxicity  L929 fibroblast-derived cells: LC50=55 µM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02470

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C97H164N24O23

Absent amino acids  CEHIMNPQRSWY

Common amino acids  K

Mass  235578

Pl  10.98

Basic residues  5

Acidic residues  1

Hydrophobic residues  10

Net charge  4

Boman Index  -293

Hydrophobicity  33.16

Aliphatic Index  107.89

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  3

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 18554256

Title  Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7

Doi 10.1111/j.1747-0285.2008.00671.x

Year  2008

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_4910

DRACP is developed by Dr.Zheng's team.