This work is licensed under a Creative Commons Attribution 4.0 International License.
[Lys18] Ascaphin-8
General Information
DRACP ID DRACP02470
Peptide Name [Lys18] Ascaphin-8
Sequence GFKDLLKGAAKALVKTVKF
Sequence Length 19
UniProt ID P0CJ32
PubChem CID Not available
Origin Synthetic (Derived from Ascaphin-8)
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Blastoma | LC50=200 µM | CytoTox 96 non-radiactive cytotoxicity assay | 1 h | 1 |
Hemolytic Activity Human erythrocytes: LC50>500 µM
Normal (non-cancerous) Cytotoxicity L929 fibroblast-derived cells: LC50=55 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C97H164N24O23
Absent amino acids CEHIMNPQRSWY
Common amino acids K
Mass 235578
Pl 10.98
Basic residues 5
Acidic residues 1
Hydrophobic residues 10
Net charge 4
Boman Index -293
Hydrophobicity 33.16
Aliphatic Index 107.89
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 18554256
Title Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7
Doi 10.1111/j.1747-0285.2008.00671.x
Year 2008
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4910
This work is licensed under a Creative Commons Attribution 4.0 International License.