This work is licensed under a Creative Commons Attribution 4.0 International License.
Chemokinostatin-8
General Information
DRACP ID DRACP02514
Peptide Name Chemokinostatin-8
Sequence DGRELCLDPKENWVQRVVEKFLK
Sequence Length 23
UniProt ID P10145
PubChem CID Not available
Origin Homo sapiens (CXCL8/IL-8)
Type Native peptide
Classification
Active ACP Cancer targeted peptides Antiangiogenic
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target CXCR
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C125H201N35O36S
Absent amino acids AHIMSTY
Common amino acids EKLV
Mass 319484
Pl 6.5
Basic residues 5
Acidic residues 5
Hydrophobic residues 8
Net charge 0
Boman Index -6213
Hydrophobicity -81.74
Aliphatic Index 88.7
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 250
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 18307172
Title Novel anti-angiogenic peptides derived from ELR-containing CXC chemokines
Year 2008
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.