This work is licensed under a Creative Commons Attribution 4.0 International License.
NK19b-KR
General Information
DRACP ID DRACP02523
Peptide Name NK19b-KR
Sequence RILRGVSRRIMRRILTGRR
Sequence Length 19
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 6.6 ± 7.9% Cytotoxicity=100 μg/ml | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: <10% Hemolysis=100 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C99H189N43O22S
Absent amino acids ACDEFHKNPQWY
Common amino acids R
Mass 268715
Pl 13.35
Basic residues 8
Acidic residues 0
Hydrophobic residues 6
Net charge 8
Boman Index -9246
Hydrophobicity -58.42
Aliphatic Index 117.89
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 17389605
Title Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against Gram-negative pathogens
Year 2007
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_5056
This work is licensed under a Creative Commons Attribution 4.0 International License.