This work is licensed under a Creative Commons Attribution 4.0 International License.
NK13
General Information
DRACP ID DRACP02526
Peptide Name NK13
Sequence KISKKIMRTFLRR
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 6.4 ± 3.0% Cytotoxicity=100 μg/ml | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: <5% Hemolysis=100 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C75H137N25O16S
Absent amino acids ACDEGHNPQVWY
Common amino acids KR
Mass 189134
Pl 12.82
Basic residues 6
Acidic residues 0
Hydrophobic residues 4
Net charge 6
Boman Index -4729
Hydrophobicity -70.77
Aliphatic Index 90
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 17389605
Title Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against Gram-negative pathogens
Year 2007
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_5059
This work is licensed under a Creative Commons Attribution 4.0 International License.