NK10

General Information


DRACP ID  DRACP02527

Peptide Name   NK10

Sequence  ISKRILTGKK

Sequence Length  10

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Membrane lysis



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma Not active up to 100μg/ml MTT assay 24 h 1

Hemolytic Activity  Human erythrocytes: <5% Hemolysis=100 µg/ml

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02527

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C51H98N16O13

Absent amino acids  ACDEFHMNPQVWY

Common amino acids  K

Mass  130415

Pl  11.92

Basic residues  4

Acidic residues  0

Hydrophobic residues  3

Net charge  4

Boman Index  -2184

Hydrophobicity  -53

Aliphatic Index  117

Half Life 
  Mammalian: 1.3 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  3

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 17389605

Title  Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against Gram-negative pathogens

Doi 10.1074/jbc.M608920200

Year  2007

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.