This work is licensed under a Creative Commons Attribution 4.0 International License.
NK11
General Information
DRACP ID DRACP02528
Peptide Name NK11
Sequence KISKRILTGKK
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | Not active up to 100μg/ml | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: <5% Hemolysis=100 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C57H110N18O14
Absent amino acids ACDEFHMNPQVWY
Common amino acids K
Mass 145016
Pl 12
Basic residues 5
Acidic residues 0
Hydrophobic residues 3
Net charge 5
Boman Index -2739
Hydrophobicity -83.64
Aliphatic Index 106.36
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 17389605
Title Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against Gram-negative pathogens
Year 2007
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.