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KLW-L10-Nala
General Information
DRACP ID DRACP02533
Peptide Name KLW-L10-Nala
Sequence KWKKLLKKLXKLLKKLLK
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=1 µM | SRB assay | 3 days | 1 |
| SK-OV-3 | Ovarian serous cystadenocarcinoma | Carcinoma | IC50=0.9 µM | SRB assay | 3 days | 1 |
| SK-MEL-2 | Melanoma | Carcinoma | IC50=1.3 µM | SRB assay | 3 days | 1 |
Hemolytic Activity Human erythrocytes: 23% Hemolysis=100 µM
Normal (non-cancerous) Cytotoxicity NIH 3T3: IC50=2 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification X=NAla
Chiral L
Physicochemical Information
Formula C107H195N27O17
Absent amino acids ACDEFGHIMNPQRSTVY
Common amino acids K
Mass 254532
Pl 11.7
Basic residues 9
Acidic residues 0
Hydrophobic residues 8
Net charge 9
Boman Index -1318
Hydrophobicity -52.22
Aliphatic Index 151.67
Half Life
/
Extinction Coefficient cystines 5500
Absorbance 280nm 323.53
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16142907
Title Cell selectivity and mechanism of action of antimicrobial model peptides containing peptoid residues
Year 2005
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_5220
This work is licensed under a Creative Commons Attribution 4.0 International License.