This work is licensed under a Creative Commons Attribution 4.0 International License.
ATN-161
General Information
DRACP ID DRACP02538
Peptide Name ATN-161
Sequence PHSCN
Sequence Length 5
UniProt ID Not available
PubChem CID 9960285
Origin Fibronectin
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides Antiangiogenic Inhibitor of the integrins α5β1, αvβ3
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Integrins α5β1, αvβ3
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C21H32N8O8S
Absent amino acids ADEFGIKLMQRTVWY
Common amino acids CHNPS
Mass 62812
Pl 7.36
Basic residues 1
Acidic residues 0
Hydrophobic residues 0
Net charge 1
Boman Index -1342
Hydrophobicity -132
Aliphatic Index 0
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 18381955
Title Pharmacology of the novel antiangiogenic peptide ATN-161 (Ac-PHSCN-NH2): observation of a U-shaped dose-response curve in several preclinical models of angiogenesis and tumor growth
Doi 10.1158/1078-0432.CCR-07-4530
Year 2008
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.