PenLeu

General Information


DRACP ID  DRACP02541

Peptide Name   PenLeu

Sequence  RQIKIWFQNRRLKWKK

Sequence Length  16

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cell-penetrating peptides



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HeLa WT Human papillomavirus-related endocervical adenocarcinoma Carcinoma 50% Cytotoxicity>1000 μM MTS/PMS assay 1 h 1

Hemolytic Activity  Human erythrocytes: HD50>128 μM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02541

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C105H170N34O20

Absent amino acids  ACDEGHMPSTVY

Common amino acids  K

Mass  249645

Pl  12.83

Basic residues  7

Acidic residues  0

Hydrophobic residues  6

Net charge  7

Boman Index  -6228

Hydrophobicity  -161.25

Aliphatic Index  73.13

Half Life 
  Mammalian: 1.3 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  11000

Absorbance 280nm  733.33

Polar residues  1

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 23085001

Title  Antimicrobial and cell-penetrating properties of penetratin analogs: effect of sequence and secondary structure

Doi 10.1016/j.bbamem.2012.10.010

Year  2013

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_8797

DRACP is developed by Dr.Zheng's team.