This work is licensed under a Creative Commons Attribution 4.0 International License.
Pen13
General Information
DRACP ID DRACP02542
Peptide Name Pen13
Sequence KIWFQNRRMKWKK
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cell-penetrating peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa WT | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 50% Cytotoxicity>1000 μM | MTS/PMS assay | 1 h | 1 |
Hemolytic Activity Human erythrocytes: HD50>128 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C87H137N27O16S
Absent amino acids ACDEGHLPSTVY
Common amino acids K
Mass 206349
Pl 12.56
Basic residues 6
Acidic residues 0
Hydrophobic residues 4
Net charge 6
Boman Index -4931
Hydrophobicity -186.15
Aliphatic Index 30
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 11000
Absorbance 280nm 916.67
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23085001
Title Antimicrobial and cell-penetrating properties of penetratin analogs: effect of sequence and secondary structure
Doi 10.1016/j.bbamem.2012.10.010
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_8800
This work is licensed under a Creative Commons Attribution 4.0 International License.