This work is licensed under a Creative Commons Attribution 4.0 International License.
WR8
General Information
DRACP ID DRACP02550
Peptide Name WR8
Sequence WRRRRRRRR
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cell-penetrating peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa WT | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 50% Cytotoxicity=442 ± 66.7 μM | MTS/PMS assay | 1 h | 1 |
Hemolytic Activity Human erythrocytes: HD50>128 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C59H108N34O10
Absent amino acids ACDEFGHIKLMNPQSTVY
Common amino acids R
Mass 159657
Pl 13.35
Basic residues 8
Acidic residues 0
Hydrophobic residues 1
Net charge 8
Boman Index -11703
Hydrophobicity -410
Aliphatic Index 0
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 687.5
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23085001
Title Antimicrobial and cell-penetrating properties of penetratin analogs: effect of sequence and secondary structure
Doi 10.1016/j.bbamem.2012.10.010
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_8812
This work is licensed under a Creative Commons Attribution 4.0 International License.