AMP 1A analogs4

General Information


DRACP ID  DRACP02554

Peptide Name   AMP 1A analogs4

Sequence  GFXGXXXGXFXGXGXXXXXX

Sequence Length  20

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
CFPAC-1 Cystic fibrosis; Pancreatic ductal adenocarcinoma; Cystic fibrosis Carcinoma IC50=2.7 μM CellTiter-Glo assay 72 h 1
MCF-7 Invasive breast carcinoma of no special type Carcinoma IC50=3 μM CellTiter-Glo assay 72 h 1
IGROV-1 Ovarian endometrioid adenocarcinoma; Endometrioid carcinoma of ovary Carcinoma IC50=2.3 μM CellTiter-Glo assay 72 h 1
COLO 205 Colon adenocarcinoma Carcinoma IC50=6.4 μM CellTiter-Glo assay 72 h 1
DLD-1 Colon adenocarcinoma Carcinoma IC50=2.6 μM CellTiter-Glo assay 72 h 1
UACC-62 Melanoma Carcinoma IC50=1.9 μM CellTiter-Glo assay 72 h 1
Mia PaCa-2 Pancreatic ductal adenocarcinoma Carcinoma IC50=4.4 μM CellTiter-Glo assay 72 h 1
A498 Renal cell carcinoma Carcinoma IC50=2.1 μM CellTiter-Glo assay 72 h 1
PC-3 Prostate carcinoma Carcinoma IC50=6.5 μM CellTiter-Glo assay 72 h 1
A549 Lung adenocarcinoma Carcinoma IC50=2.4 μM CellTiter-Glo assay 72 h 1
NCI-H69 Lung small cell carcinoma; Small cell lung cancer Carcinoma IC50=1.5 μM CellTiter-Glo assay 72 h 1
RL Diffuse large B-cell lymphoma Lymphoma IC50=1.7 μM CellTiter-Glo assay 72 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  X(3/5/7/9/11/13/16)=A6c (1-aminocyclohexane carboxylic acid); X(6/15/17/18/19/20)=Dab (Diaminobutyric acid)

Chiral  L



Physicochemical Information


Formula  C28H9N7O-5

Absent amino acids  ACDEHIKLMNPQRSTVWY

Common amino acids  X

Mass  213249

Pl  6.11

Basic residues  0

Acidic residues  0

Hydrophobic residues  2

Net charge  0

Boman Index  1066

Hydrophobicity  18

Aliphatic Index  0

Half Life 
  /

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  5

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 27387357

Title  Antibacterial and anticancer activity of a series of novel peptides incorporating cyclic tetra-substituted C(α) amino acids

Doi 10.1016/j.bmc.2016.06.048

Year  2016

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_9500

DRACP is developed by Dr.Zheng's team.