This work is licensed under a Creative Commons Attribution 4.0 International License.
AMP 1A analogs5
General Information
DRACP ID DRACP02555
Peptide Name AMP 1A analogs5
Sequence GFXGXXXGXFXGXGXXXXXX
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| CFPAC-1 | Cystic fibrosis; Pancreatic ductal adenocarcinoma; Cystic fibrosis | Carcinoma | Not determined | CellTiter-Glo assay | 72 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | Not determined | CellTiter-Glo assay | 72 h | 1 |
| IGROV-1 | Ovarian endometrioid adenocarcinoma; Endometrioid carcinoma of ovary | Carcinoma | Not determined | CellTiter-Glo assay | 72 h | 1 |
| COLO 205 | Colon adenocarcinoma | Carcinoma | Not determined | CellTiter-Glo assay | 72 h | 1 |
| DLD-1 | Colon adenocarcinoma | Carcinoma | Not determined | CellTiter-Glo assay | 72 h | 1 |
| UACC-62 | Melanoma | Carcinoma | Not determined | CellTiter-Glo assay | 72 h | 1 |
| Mia PaCa-2 | Pancreatic ductal adenocarcinoma | Carcinoma | Not determined | CellTiter-Glo assay | 72 h | 1 |
| A498 | Renal cell carcinoma | Carcinoma | Not determined | CellTiter-Glo assay | 72 h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | Not determined | CellTiter-Glo assay | 72 h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | Not determined | CellTiter-Glo assay | 72 h | 1 |
| NCI-H69 | Lung small cell carcinoma; Small cell lung cancer | Carcinoma | Not determined | CellTiter-Glo assay | 72 h | 1 |
| RL | Diffuse large B-cell lymphoma | Lymphoma | Not determined | CellTiter-Glo assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification X(3/5/7/9/11/13/16)=A6c (1-aminocyclohexane carboxylic acid); X(6/15/17/18/19/20)=Dpr (Diaminopropionic acid)
Chiral L
Physicochemical Information
Formula C28H9N7O-5
Absent amino acids ACDEHIKLMNPQRSTVWY
Common amino acids X
Mass 213249
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 2
Net charge 0
Boman Index 1066
Hydrophobicity 18
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27387357
Title Antibacterial and anticancer activity of a series of novel peptides incorporating cyclic tetra-substituted C(α) amino acids
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.