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WK1
General Information
DRACP ID DRACP02562
Peptide Name WK1
Sequence WKpGKW
Sequence Length 6
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis β-hairpin peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| RAW 264.7 | Mouse leukemia | Leukemia | <10% Killing=128 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: 5% Hemolysis=512 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification p=D-Pro
Chiral Mix
Physicochemical Information
Formula C36H47N9O5
Absent amino acids ACDEFHILMNPQRSTVY
Common amino acids KW
Mass 77519
Pl 10.81
Basic residues 2
Acidic residues 0
Hydrophobic residues 2
Net charge 2
Boman Index -550
Hydrophobicity -166.67
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 11000
Absorbance 280nm 2200
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26088720
Title Antimicrobial activity and membrane-active mechanism of tryptophan zipper-like β-hairpin antimicrobial peptides
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_9885
This work is licensed under a Creative Commons Attribution 4.0 International License.