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WK4
General Information
DRACP ID DRACP02565
Peptide Name WK4
Sequence WKWKWKWKpGKWKWKWKW
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis β-hairpin peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| RAW 264.7 | Mouse leukemia | Leukemia | 35.58% Killing=128 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: 5% Hemolysis=8 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification p=D-Pro
Chiral Mix
Physicochemical Information
Formula C138H179N33O17
Absent amino acids ACDEFHILMNPQRSTVY
Common amino acids KW
Mass 287555
Pl 11.65
Basic residues 8
Acidic residues 0
Hydrophobic residues 8
Net charge 8
Boman Index -2482
Hydrophobicity -215.56
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 44000
Absorbance 280nm 2588.24
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26088720
Title Antimicrobial activity and membrane-active mechanism of tryptophan zipper-like β-hairpin antimicrobial peptides
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_9888
This work is licensed under a Creative Commons Attribution 4.0 International License.