This work is licensed under a Creative Commons Attribution 4.0 International License.
peptide 1
General Information
DRACP ID DRACP02567
Peptide Name peptide 1
Sequence KKWWKKWWK
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A20 | Murine B cell lymphoma | Lymphoma | IC50=37.3 ± 1.5 µM | MTT assay | 4 h | 1 |
| AT84 | Murine squamous cell carcinoma | Carcinoma | IC50=31.0 ± 1.0 µM | MTT assay | 4 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity MRC-5: IC50>357 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C74H102N18O10
Absent amino acids ACDEFGHILMNPQRSTVY
Common amino acids K
Mass 154661
Pl 11.4
Basic residues 5
Acidic residues 0
Hydrophobic residues 4
Net charge 5
Boman Index -1843
Hydrophobicity -256.67
Aliphatic Index 0
Half Life
Mammalian: 2.8 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 22000
Absorbance 280nm 2750
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26982623
Title Discovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide
Doi 10.1021/acs.jmedchem.5b02025
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_11875
This work is licensed under a Creative Commons Attribution 4.0 International License.