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peptide 16
General Information
DRACP ID DRACP02580
Peptide Name peptide 16
Sequence RRWXRRWWR
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A20 | Murine B cell lymphoma | Lymphoma | IC50=6.7 ± 1.2 µM | MTT assay | 4 h | 1 |
| AT84 | Murine squamous cell carcinoma | Carcinoma | IC50=11.3 ± 2.1 µM | MTT assay | 4 h | 1 |
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | IC50=6.7 ± 3.7 µM | MTT assay | 4 h | 1 |
| HL-60/ADR | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | IC50=6.0 ± 4.5 µM | MTT assay | 4 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=5.5 ± 0.9 µM | MTT assay | 4 h | 1 |
| MCF-7/mdr | Invasive breast carcinoma of no special type | Carcinoma | IC50=6.6 ± 2.8 µM | MTT assay | 4 h | 1 |
| IGROV-1 | Ovarian endometrioid adenocarcinoma; Endometrioid carcinoma of ovary | Carcinoma | IC50=11.1 ± 3.4 µM | MTT assay | 4 h | 1 |
| IGROV-1/CDDP | Ovarian endometrioid adenocarcinoma; Endometrioid carcinoma of ovary | Carcinoma | IC50=5.5 ± 2.2 µM | MTT assay | 4 h | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=7.0 ± 0.8 µM | MTT assay | 4 h | 1 |
| K562/Gleevec | Blast phase chronic myelogenous leukemia, BCR-ABL5 positive; Chronic myeloid leukemia | Leukemia | IC50=7.7 ± 1.6 µM | MTT assay | 4 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity MRC-5: IC50=76.0 ± 9.5 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification X=Dip (Diphenylalanine)
Chiral L
Physicochemical Information
Formula C63H90N26O8
Absent amino acids ACDEFGHIKLMNPQSTVY
Common amino acids R
Mass 159243
Pl 13.1
Basic residues 5
Acidic residues 0
Hydrophobic residues 3
Net charge 5
Boman Index -6761
Hydrophobicity -280
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 16500
Absorbance 280nm 2062.5
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26982623
Title Discovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide
Doi 10.1021/acs.jmedchem.5b02025
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_11905
This work is licensed under a Creative Commons Attribution 4.0 International License.