This work is licensed under a Creative Commons Attribution 4.0 International License.
peptide 17
General Information
DRACP ID DRACP02581
Peptide Name peptide 17
Sequence kkWXkkWWk
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A20 | Murine B cell lymphoma | Lymphoma | IC50=134 ± 13 µM | MTT assay | 4 h | 1 |
| AT84 | Murine squamous cell carcinoma | Carcinoma | IC50=113 ± 10 µM | MTT assay | 4 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity MRC-5: IC50>347 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification k=D-Lys; X=Dip (Diphenylalanine)
Chiral Mix
Physicochemical Information
Formula C33H20N6O-2
Absent amino acids ACDEFGHIKLMNPQRSTVY
Common amino acids W
Mass 72143
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 3
Net charge 0
Boman Index 699
Hydrophobicity -30
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 16500
Absorbance 280nm 2062.5
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26982623
Title Discovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide
Doi 10.1021/acs.jmedchem.5b02025
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_11906
This work is licensed under a Creative Commons Attribution 4.0 International License.