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LTX-315 Metabolites 3
General Information
DRACP ID DRACP02584
Peptide Name LTX-315 Metabolites 3
Sequence WKKWXK
Sequence Length 6
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A20 | Murine B cell lymphoma | Lymphoma | IC50=247 ± 13 µM | MTT assay | 4 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity MRC-5: IC50=460 ± 71 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification X=Dip (Diphenylalanine)
Chiral L
Physicochemical Information
Formula C40H56N10O5
Absent amino acids ACDEFGHILMNPQRSTVY
Common amino acids K
Mass 95631
Pl 11.1
Basic residues 3
Acidic residues 0
Hydrophobic residues 2
Net charge 3
Boman Index -1199
Hydrophobicity -225
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 11000
Absorbance 280nm 2200
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26982623
Title Discovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide
Doi 10.1021/acs.jmedchem.5b02025
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.