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Kalata B1 [W23WW]
General Information
DRACP ID DRACP02590
Peptide Name Kalata B1 [W23WW]
Sequence GLPVCGETCVGGTCNTPGCTCSWWPVCTRN
Sequence Length 30
UniProt ID P56254
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | CC50=9.8±0.5 μM | Resazurin assay | 2, 24 h | 1 |
| MM96L | Melanoma | Carcinoma | CC50=12.2±0.6 μM | Resazurin assay | 2, 24 h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=14.0±0.7 µM
Normal (non-cancerous) Cytotoxicity HFF-1: CC50=9.2±0.7 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys5<--->Cys19; Cys9<--->Cys21; Cys14<--->Cys27; NCB: Gly1<--->Asn30
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C128H197N37O41S6
Absent amino acids ADFHIKMQY
Common amino acids C
Mass 362001
Pl 5.94
Basic residues 1
Acidic residues 1
Hydrophobic residues 6
Net charge 0
Boman Index -1718
Hydrophobicity 11.67
Aliphatic Index 42
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 11375
Absorbance 280nm 392.24
Polar residues 19
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25099014
Title Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_12211
This work is licensed under a Creative Commons Attribution 4.0 International License.