This work is licensed under a Creative Commons Attribution 4.0 International License.
PBP
General Information
DRACP ID DRACP02592
Peptide Name PBP
Sequence KKLIKVWAKGFKKAKKLFKGIG
Sequence Length 22
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 21% Cytotoxicity=15 µM | CellTiter-Blue assay | 24 h | 1 |
Hemolytic Activity Sheep erythrocytes: 10% Hemolysis=15 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C124H210N32O23
Absent amino acids CDEHMNPQRSTY
Common amino acids K
Mass 289200
Pl 11.7
Basic residues 9
Acidic residues 0
Hydrophobic residues 10
Net charge 9
Boman Index -1150
Hydrophobicity -32.73
Aliphatic Index 93.18
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 261.9
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30637367
Title Antimicrobial activity of a porphyrin binding peptide
Doi 110(4):e24074. doi: 10.1002/pep2.24074
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_12363
This work is licensed under a Creative Commons Attribution 4.0 International License.