Wollamide A

General Information


DRACP ID  DRACP02601

Peptide Name   Wollamide A

Sequence  WLlXNx

Sequence Length  6

UniProt ID  Not available

PubChem CID  139588306 

Origin  Streptomyces nov. sp.

Type  Native peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
NCI-H460 Lung large cell carcinoma Carcinoma Not active up to 30 µM MTT assay 68 h 1
SW620 Colon adenocarcinoma Carcinoma Not active up to 30 µM MTT assay 68 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  NCB: Trp1<--->Gly6

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  X=Allo-Ile; x=D-Orn

Chiral  Mix



Physicochemical Information


Formula  C21H23N5O2

Absent amino acids  ACDEFGHIKMPQRSTVY

Common amino acids  LNWX

Mass  57681

Pl  6.11

Basic residues  0

Acidic residues  0

Hydrophobic residues  2

Net charge  0

Boman Index  61

Hydrophobicity  -10

Aliphatic Index  65

Half Life 
  /

Extinction Coefficient cystines  5500

Absorbance 280nm  1100

Polar residues  1

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 25229313

Title  Wollamides: antimycobacterial cyclic hexapeptides from an Australian soil Streptomyces

Doi 10.1021/ol502472c

Year  2014

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPN_7161

DRACP is developed by Dr.Zheng's team.