This work is licensed under a Creative Commons Attribution 4.0 International License.
Wollamide A
General Information
DRACP ID DRACP02601
Peptide Name Wollamide A
Sequence WLlXNx
Sequence Length 6
UniProt ID Not available
PubChem CID 139588306
Origin Streptomyces nov. sp.
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| NCI-H460 | Lung large cell carcinoma | Carcinoma | Not active up to 30 µM | MTT assay | 68 h | 1 |
| SW620 | Colon adenocarcinoma | Carcinoma | Not active up to 30 µM | MTT assay | 68 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Trp1<--->Gly6
N-terminal Modification Free
C-terminal Modification Free
Other Modification X=Allo-Ile; x=D-Orn
Chiral Mix
Physicochemical Information
Formula C21H23N5O2
Absent amino acids ACDEFGHIKMPQRSTVY
Common amino acids LNWX
Mass 57681
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 2
Net charge 0
Boman Index 61
Hydrophobicity -10
Aliphatic Index 65
Half Life
/
Extinction Coefficient cystines 5500
Absorbance 280nm 1100
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25229313
Title Wollamides: antimycobacterial cyclic hexapeptides from an Australian soil Streptomyces
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_7161
This work is licensed under a Creative Commons Attribution 4.0 International License.