This work is licensed under a Creative Commons Attribution 4.0 International License.
Wollamide B
General Information
DRACP ID DRACP02602
Peptide Name Wollamide B
Sequence WLlVNx
Sequence Length 6
UniProt ID Not available
PubChem CID 102341742
Origin Streptomyces nov. sp.
Type Native peptide
Classification
Targeted peptide conjugates
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| NCI-H460 | Lung large cell carcinoma | Carcinoma | Not active up to 30 µM | MTT assay | 68 h | 1 |
| SW620 | Colon adenocarcinoma | Carcinoma | Not active up to 30 µM | MTT assay | 68 h | 1 |
| HepG2 | Hepatoblastoma | Blastoma | IC50=56 µM | CellTiter-Glo assay | Not available | 2 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Trp1<--->Gly6
N-terminal Modification Free
C-terminal Modification Free
Other Modification x=D-Orn
Chiral Mix
Physicochemical Information
Formula C26H34N6O4
Absent amino acids ACDEFGHIKMPQRSTY
Common amino acids LNVW
Mass 58396
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 3
Net charge 0
Boman Index 465
Hydrophobicity 60
Aliphatic Index 113.33
Half Life
/
Extinction Coefficient cystines 5500
Absorbance 280nm 1100
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25229313
Title Wollamides: antimycobacterial cyclic hexapeptides from an Australian soil Streptomyces
Year 2014
Literature 2
Pubmed ID 28423019
Title Design, synthesis and structure-activity relationship study of wollamide B; a new potential anti TB agent
Doi 10.1371/journal.pone.0176088
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_7162
This work is licensed under a Creative Commons Attribution 4.0 International License.