This work is licensed under a Creative Commons Attribution 4.0 International License.
NRC-03B
General Information
DRACP ID DRACP02613
Peptide Name NRC-03B
Sequence GRRKRKWLRRIGKGVKIIGGAALDHL
Sequence Length 26
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | 50% Cell death=8 µg/ml | MTT assay | 2 h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis>256 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Biotin
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C132H232N48O29
Absent amino acids CEFMNPQSTY
Common amino acids GR
Mass 340172
Pl 12.69
Basic residues 10
Acidic residues 1
Hydrophobic residues 10
Net charge 9
Boman Index -6597
Hydrophobicity -57.69
Aliphatic Index 108.85
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 220
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21729875
Title The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_5367
This work is licensed under a Creative Commons Attribution 4.0 International License.