NRC-03B

General Information


DRACP ID  DRACP02613

Peptide Name   NRC-03B

Sequence  GRRKRKWLRRIGKGVKIIGGAALDHL

Sequence Length  26

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HL-60 Adult acute myeloid leukemia; Acute myeloid leukemia Leukemia 50% Cell death=8 µg/ml MTT assay 2 h 1

Hemolytic Activity  Human erythrocytes: 50% Hemolysis>256 µg/ml

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02613

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Biotin

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C132H232N48O29

Absent amino acids  CEFMNPQSTY

Common amino acids  GR

Mass  340172

Pl  12.69

Basic residues  10

Acidic residues  1

Hydrophobic residues  10

Net charge  9

Boman Index  -6597

Hydrophobicity  -57.69

Aliphatic Index  108.85

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  5500

Absorbance 280nm  220

Polar residues  5

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 21729875

Title  The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents

Doi 10.1242/dmm.007310

Year  2011

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_5367

DRACP is developed by Dr.Zheng's team.