This work is licensed under a Creative Commons Attribution 4.0 International License.
Frenatin 2.1S
General Information
DRACP ID DRACP02614
Peptide Name Frenatin 2.1S
Sequence GLVGTLLGHIGKAILG
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Sphaenorhynchus lacteus
Type Native peptide
Classification
Active ACP Immune system stimulating peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | LC50=80 ± 6 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: HC50=167 ± 8 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C70H123N19O18
Absent amino acids CDEFMNPQRSWY
Common amino acids G
Mass 178663
Pl 9.7
Basic residues 2
Acidic residues 0
Hydrophobic residues 8
Net charge 2
Boman Index 2729
Hydrophobicity 127.5
Aliphatic Index 170.63
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24704757
Title A family of antimicrobial and immunomodulatory peptides related to the frenatins from skin secretions of the Orinoco lime frog Sphaenorhynchus lacteus (Hylidae)
Doi 10.1016/j.peptides.2014.03.020
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_5369
This work is licensed under a Creative Commons Attribution 4.0 International License.