This work is licensed under a Creative Commons Attribution 4.0 International License.
Frenatin 2.2S
General Information
DRACP ID DRACP02615
Peptide Name Frenatin 2.2S
Sequence GLVGTLLGHIGKAILS
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Sphaenorhynchus lacteus
Type Native peptide
Classification
Active ACP Immune system stimulating peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | LC50=65 ± 5 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: HC50=169 ± 7 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C71H125N19O19
Absent amino acids CDEFMNPQRWY
Common amino acids GL
Mass 181665
Pl 9.7
Basic residues 2
Acidic residues 0
Hydrophobic residues 8
Net charge 2
Boman Index 2295
Hydrophobicity 125
Aliphatic Index 170.63
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24704757
Title A family of antimicrobial and immunomodulatory peptides related to the frenatins from skin secretions of the Orinoco lime frog Sphaenorhynchus lacteus (Hylidae)
Doi 10.1016/j.peptides.2014.03.020
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_5370
This work is licensed under a Creative Commons Attribution 4.0 International License.