This work is licensed under a Creative Commons Attribution 4.0 International License.
Ctry2459-H3
General Information
DRACP ID DRACP02619
Peptide Name Ctry2459-H3
Sequence FLHFLHHLF
Sequence Length 9
UniProt ID P0DMF3
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Huh7.5.1 | Adult hepatocellular carcinoma | Carcinoma | CC50>500 µg/ml | MTT assay | 48 h | 1 |
Hemolytic Activity Human erythrocytes: HC50=416.4 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antiviral
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C63H83N15O10
Absent amino acids ACDEGIKMNPQRSTVWY
Common amino acids FHL
Mass 135333
Pl 7.81
Basic residues 3
Acidic residues 0
Hydrophobic residues 6
Net charge 3
Boman Index 972
Hydrophobicity 113.33
Aliphatic Index 130
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23415044
Title Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus
Doi 10.1016/j.biomaterials.2013.01.075
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_5445
This work is licensed under a Creative Commons Attribution 4.0 International License.