This work is licensed under a Creative Commons Attribution 4.0 International License.
Gageostatin A
General Information
DRACP ID DRACP02620
Peptide Name Gageostatin A
Sequence ELLVDLL
Sequence Length 7
UniProt ID Not available
PubChem CID 139585758
Origin Bacillus subtilis
Type Native peptide
Classification
Active ACP Lipopeptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=14.9 µg/mL | SBR assay | 48 h | 1 |
| HCT 15 | Colon adenocarcinoma | Carcinoma | IC50=11.4 µg/mL | SBR assay | 48 h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=10.8 µg/mL | SBR assay | 48 h | 1 |
| NCI-H23 | Lung adenocarcinoma | Carcinoma | IC50=11.2 µg/mL | SBR assay | 48 h | 1 |
| NUGC-3 | Gastric adenocarcinoma | Carcinoma | IC50=11.8 µg/mL | SBR assay | 48 h | 1 |
| ACHN | Papillary renal cell carcinoma | Carcinoma | IC50=11.5 µg/mL | SBR assay | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification 3-β-hydroxy-11-methyltridecanoic
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C38H67N7O12
Absent amino acids ACFGHIKMNPQRSTWY
Common amino acids L
Mass 92121
Pl 3.55
Basic residues 0
Acidic residues 2
Hydrophobic residues 5
Net charge -2
Boman Index 819
Hydrophobicity 177.14
Aliphatic Index 264.29
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24492520
Title Gageostatins A-C, antimicrobial linear lipopeptides from a marine Bacillus subtilis
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_5449
This work is licensed under a Creative Commons Attribution 4.0 International License.